thomas chang ubc

The present study investigated the effects of NNRTIs on the activity of pregnane X receptor (PXR) and constitutive androstane receptor (CAR), key transcriptional factors regulating the expression of various drug-metabolizing enzymes and transporters. "Killam Faculty Research Fellowship". Selected Publications Wang, Shuo, Henry An, Wei-Yew Chang, Chris Gaston, and Barb Thomas (2020). The overall experimental strategy was to modulate the in situ formation of these two metabolites and determine the consequences on VPA toxicity in sandwich-cultured rat hepatocytes. Email: ... Our group has extensive collaborations with researchers at UBC Chemistry. The overall goal of Dr. Chang’s research program is to enhance our understanding of the molecular and cellular determinants that regulate the transport, bioactivation and detoxification of drugs, and how they affect inter-individual differences in drug action. Nuclear receptors are evolutionarily-related DNA-binding transcription factors that regulate the expression of a broad array of genes involved in various biological processes. She held a Canada Research Chair (Tier 2) in Disaster Management and Urban Sustainability from 2004 to 2013. Shawn Chang, 3rd year Science student (Combined Honours in Biochemistry and Forensic Science) You can learn what you really love “I think the biggest difference between uni and high school is that in university, you have the autonomy to choose topics that you actually want to learn about. The Southern Medical Program (SMP) at UBC Okanagan campus is educating the next generation of doctors, fostering new discoveries, and building new pathways to improve health for communities across the Interior Health region. Alternatively, you may have mistakenly bookmarked the web login form instead of the actual web site you wanted to bookmark or used a link created by somebody else who made the same mistake. Currently an Assistant Professor at the UBC Institute for the Oceans and Fisheries, Tom works on quantitative solutions to critical fishery management problems. The role of the allowable cut effect on the benefits of adopting genomic technology in the Alberta forest sector Canadian Journal of Agricultural Economics/Revue canadienne d'agroeconomie W-Y Chang, C Gaston, J Cool, and B Thomas (2019). In order to examine the effect of lipid digestion on absorption of poorly water soluble drugs from SNEDDS the lipase inhibitor orlistat (tetrahydrolipstatin) was used. The mechanism of VPA hepatotoxicity is not known, but it may involve reactive metabolites of VPA. The study revealed that precipitation onlywas evident in the stomach, thus precipitation in the intestinal in vitro modelmay be an artifact and may require the addition of an in vitro gastric digestion step to be predictive in vivo.View record, Valproic acid (VPA) is a widely prescribed broad-spectrum antiepileptic drug. (Raphael Auer; Thomas Chaney; and Philip Saure) January 2018, 110: 87-102 | | | Journal of International Economics ©2018 by Elsevier. Currently, Dr. Chang is Professor and Associate Dean, Graduate and Postdoctoral Studies and a UBC Distinguished University Scholar. Rilpivirine and rifampin did not affect PXR expression, but it decreased endogenous expression of hsa-miR-18a-5p in LS180 cells. Stephanie E. Chang is a UBC professor with a joint appointment in the School of Community and Regional Planning and the Institute for Resources, Environment, and Sustainability. Various studies are ongoing to investigate the functionality of naturally occurring splice variants of the human constitutive androstane receptor (e.g. 1998. The relationships between the various pathophysiological findings of VPA-induced hepatotoxicity and the role of VPA biotransformation in the induction of hepatotoxicity have not been systematically investigated. Credits that have an established equivalent between campuses can be used to satisfy course-specific degree requirements. Thomas Chang è su Facebook. These nuclear receptors include constitutive androstane receptor (CAR) and pregnane X receptor (PXR). Find contact's direct phone number, email address, work history, and more. Elaine has 6 jobs listed on their profile. Lipid-based drug delivery systems (LbDDS) are a versatile group of formulations including self-nanoemulsifying drug delivery systems (SNEDDS). The effects of glutathione supplementation on the attenuation of the markers for VPA-induced toxicities were investigated. Demonstrate that you are familiar with their research: Convey the specific ways you are a good fit for the program. For both halofantrine and fenofibrate there was a significant increase of Cmax for the super-SNEDDS compared to the SNEDDS. Rilpivirine, etravirine, and efavirenz, but not nevirapine or delavirdine, were identified as agonists of PXR and inducers of cytochrome P450 3A4 (CYP3A4), a target gene of PXR. The present thesis compared the effects of VPA, synthesized VPA metabolites, and alpha-F-VPA on markers of mitochondrial dysfunction (WST-1), cytotoxicity (LDH), oxidative stress (DCF), and glutathione (GSH) depletion in a novel model of sandwich-cultured rat hepatocytes (SCRH). Using a sandwich-cultured rat hepatocyte model, the present work investigated the toxicity of two specific VPA metabolites, (E)-2,4-diene-VPA and valproyl-1-O-β acyl glucuronide (VPA-G), and their role in the hepatocyte toxicity of VPA. Suppression or induction of these enzymes in testis may alter the magnitude of tissue exposure to xenobiotics and endobiotics levels. You may be seeing this page because you used the Back button while browsing a secure web site or application. Do not send non-specific, mass emails to everyone in the department hoping for a match. Thomas Chang (UBC Professor): Pharmacology, Nuclear Receptor, Drug-Metabolizing Enzymes, Cytochrome P450, Gene Expression, Gene regulation Studies are underway that focus on natural products and synthetic drugs. VPA toxicity was assessed by markers such as 2′,7′-dichlorofluorescein formation (oxidative stress), BODIPY 558/568 C12 accumulation (steatosis), lactate dehydrogenase release (necrosis), and cellular content of total glutathione (antioxidant status). Clinical use of VPA is associated with a rare, but possibly fatal, idiosyncratic hepatotoxicity. GSH may serve a protective role against VPA-induced oxidative stress in SCRH. Position Title: Adjunct Professor. Story submitted by. K. J. Elwood, “ Performance of Concrete Buildings in the 22 February 2011 Christchurch Earthquake and Implications for Canadian Codes ”, Canadian Journal of Civil Engineering, 2013.. Google Scholar; BibTex To further understand PXR regulation by rilpivirine, the role of microRNA in rilpivirine activation of PXR was investigated. The Changeling by Thomas Middleton and William Rowley Directed by MFA Director Luciana Silvestre Fernandes. Dr. Chang’s research program is supported by the Canadian Institutes of Health Research and the Michael Smith Foundation for Health Research. Functional Analysis of Splice Variants of Nuclear Receptors. Cane Kong has uploaded 2266 photos to Flickr. From the reaction phenotyping experiments, CYP2C9 was the major catalyst for the formation of 4-ene-VPA, 4-OH-VPA, and 5-OH-VPA in human liver microsomes, whereas CYP2A6 contributed partially to 3-OH-VPA formation. Consistent with this finding, alpha-F-VPA, which is resistant to bioactivation by several biotransformation pathways, was nontoxic. As shown in Study 1, immunoblot analysis of testicular microsomes prepared from untreated rats revealed the presence of CYP1B1, CYP2A1, CYP17A1, NADPH-cytochrome P450 reductase (POR) and mEH, and absence of CYP1A1, CYP1A2, CYP2B1, CYP2E1, CYP2D1, CYP2D2, CYP2C6, CYP2C7, CYP2C11, CYP2C12, CYP2C13, CYP3A1, CYP3A2, CYP4A1, CYP4A2 and CYP4A3. Overall, the results of the present study add value to the existing knowledge on the role of reactive metabolites of VPA in VPA hepatotoxicity. And most specially, I want to give my deep gratitude to the long-serving co-managing directors, Joyce Hinton and Cameron McGill, and several other staff members as well, who have been here since the beginning. Overall, these findings add significant knowledge to the role of VPA and its metabolites in the induction of hepatotoxicity and how VPA is metabolized in humans.View record, Relatively little is known about the expression, localization and regulation of rat testicular xenobiotic-metabolizing enzymes, including cytochrome P450s (CYP) and microsomal epoxide hydrolase (mEH), which are involved in the metabolism of xenobiotics including drugs and toxicants, and of endobiotics such as steroid hormones and prostaglandins. The advantage of using LbDDS, such as SNEDDS, for poorly water soluble drugs is that typically the oral bioavailability is increased compared to traditional solid dosage forms. Canadian Institute of Health Research and Rx&D Health Research Foundation. Alice Chang Project Coordinator (BeeHIVE Research Cluster) Project Manager (PCIGR) EOS South 359 (604) 822-3458. Be sure to visit the, Check whether the program requires you to seek commitment from a supervisor prior to submitting an application. Reporter gene assays revealed a functional hsa-miR-18a-5p microRNA recognition element in the 3′-untranslated region of PXR. 1997-2001. I finished my Ph.D. in statistics at the University of British Columbia. This means credits from a different campus will not be converted to transfer credit but may have a course equivalency. In Study 3, administration of BPA at 400, 800 or 1600 μmol/kg sc once daily for 14 days decreased testicular CYP1B1, CYP2A1, CYP17A1, mEH and POR protein expression at each of the dosages tested. British Columbia Health Research Foundation. In summary, CYP1B1, CYP2A1, CYP17A1, mEH and POR were detected in rat testis and their expression was confined to interstitial cells (CYP1B1, CYP2A1, CYP17A1, mEH and POR) and seminiferous tubules (mEH and POR). thomas.chang@ubc.ca. Thomas SchneiderProfessor of Egyptology and Near Eastern Studiesthomas.schneider@ubc.cawork phone: 604-827-4316 Establish that your research interests align with the faculty member’s research interests. Compose an error-free and grammatically correct email addressed to your specifically targeted faculty member, and remember to use their correct titles. Your contact should be genuine rather than generic. I am a software engineer at Google Brain, based in Toronto, Canada. Vancouver, Canada. Google Scholar; BibTex Izaak Walton Killam Trust. staff. Michael Smith Foundation for Health Research. Office of the Associate Dean, Graduate and Postdoctoral Studies . Alice coordinates research activities, events and meetings for BeeHIVE, a UBC-based research excellence cluster. Ensure to craft compelling answers to these questions. To rebook or refund preview tickets, please contact box.office@ubc… EB and BPA did not produce a general down-regulation of testicular protein expression because neither of these chemicals decreased calnexin protein (endoplasmic reticulum marker) levels. Time-dependent effects of VPA on GSH depletion were characterized in relation to the effects of VPA on the WST-1, LDH, and DCF markers. steroid hormones, vitamins, bile acids). In Study 2, subcutaneous (sc) treatment of EB at 0.004, 0.04, 0.4 or 4 μmol/kg once daily for 14 days suppressed testicular expression of CYP1B1, CYP2A1 and CYP17A1 at each of the dosages tested. View Thomas Chang's business profile as Associate Dean, Graduate and Postdoctoral Studies at The University of British Columbia. These data suggest that hsa-miR-18a-5p regulates PXR and contributes to drug activation of PXR. People & Change: Thomas Veal October 24, 2019. Current Student - Faculty of Arts In contrast, over-expression of hsa-miR-18a-5p decreased PXR mRNA expression and CYP3A4 inducibility by rilpivirine and rifampin. Include a brief outline of your academic background, why you are interested in working with the faculty member, and what experience you could bring to the department. Bioinformatic analysis (www.microRNA.org) predicted sequence complementarity between hsa-miR-18a-5p and PXR. There are 48 known members in the superfamily of nuclear receptors in the human genome. The contribution of the CYP- and UGT-mediated biotransformation of VPA in VPA-induced toxicity was also examined. He pursued his postdoctoral studies in the Division of Cancer Pharmacology at the Dana-Farber Cancer Institute and the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School. BeeHIVE PCIGR. (E)-2-ene-VPA, which is a β-oxidation metabolite of VPA, was also included in the experiments concerning (E)-2,4-diene-VPA, as it formed relatively large amounts of (E)-2,4-diene-VPA. G+PS regularly provides virtual sessions that focus on admission requirements and procedures and tips how to improve your application. Be certain that their research is indeed what you are hoping to study. Among the NNRTIs investigated, only efavirenz activated the SV23 and SV24 splice variants of CAR, indicating that NNRTIs activated CAR in a drug-specific and isoform-selective manner. Chang TKH. Thus, it is important to identify chemical modulators of these receptors. The supervision enquiry form guides you with targeted questions. "Research Scholar Award". Dr. Thomas K. H. Chang completed a bachelor of science and a doctor of philosophy in pharmaceutical sciences at UBC. UBC courses are eligible for credit towards a UBC degree program on either campus. In the present study, constitutive expression of various xenobiotic-metabolizing enzymes (Study 1) and their regulation by 17β-estradiol benzoate (EB) (Study 2) and an endocrine disrupting chemical, bisphenol A (BPA) (Study 3), were investigated in adult rat testis. Address the faculty members by name. drugs, environmental chemicals) and endogenous substances (e.g. Join Facebook to connect with Thomas Chang and others you may know. There are many splice variants of the human constitutive androstane receptor, several of which are expressed predominantly in the liver. Other studies include elucidating the cellular and molecular mechanisms by which drugs and other chemicals activate constitutive androstane receptor and pregnane X receptor, and identifying the various factors that regulate the expression and function of these nuclear receptors. Prior to that, I was a machine learning researcher at Borealis AI. According to the findings with β-naphthoflavone and borneol, in situ generated VPA-G did not appear to be toxic to sandwich-cultured rat hepatocytes and was unlikely to contribute to the hepatocyte toxicity of VPA. Liquidity Constrained Exporters (Thomas Chaney) November 2016, 72: 141-54 | | Journal of Economic Dynamics and Control ©2016 by Elsevier. A. G. Sanjuan and Froese, T., “ The Application of Project Management Standards and Success Factors to the Development of a Project Management Assessment Tool ”, Procedia - Social and Behavioural Sciences Journal, vol. Pharmaceutical Sciences: Dr. Thomas Chang; Sauder School of Business: Dr. John Ries; Science: Dr. Mark MacLachlan; Faculty PDF Coordinators or Postdoctoral Fellows at UBC Vancouver may refer an issue to the Postdoctoral Fellows Office. Urine samples from children on VPA therapy were assayed to correlate levels of VPA metabolites with the lipid peroxidation marker, 15-F2t-isoprostane. NNRTI therapy is associated with pharmacokinetic drug interactions, the underlying mechanisms of which are poorly understood. Burroughs Wellcome Fund (U.S.A.). Chang TKH. He pursued his postdoctoral studies in the Division of Cancer Pharmacology at the Dana-Farber Cancer Institute and the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School. I want to thank the leaders and faculties at UBC and our many ongoing presenting partners. Halofantrine and fenofibrate were chosen as model drugs and for neither halofantrine nor fenofibrate digestion appeared to have an effect on the oral bioavailability in rats.The administration of halofantrine and fenofibrate in super-SNEDDS led to increasedbioavailability compared to SNEDDS when evaluated in a rat model in vivo. Current postdoctoral researchers Chang Lu (Aug 2018 – May 2021) Ph.D. in Strategic Management and Organization at the Alberta School of Business, University of Alberta Theoretically, he focuses on the processes by which actors instigate change in highly institutionalized contexts. If you have reviewed some of this faculty member's publications, understand their research interests and have reviewed the admission requirements, you may, Pregnane X Receptor and Constitutive Androstane Receptor Activation by Non-nucleoside HIV-1 Reverse Transcriptase Inbibitors (2016), The effect of digestion and drug load on absorption of poorly water soluble drugs from self-nanoemulsifying drug delivery systems (SNEDDS) (2016), Valproic acid biotransformation and toxicity in sandwich-cultured rat hepatocytes (2014), Valproic Acid: Mechanisms of Hepatotoxicity and Reaction Phenotyping (2010), Constitutive expression of xenobiotic-metabolizing enzymes in rat testis: Immunochemical characterization and regulation by 17-beta-estradiol benzoate and bisphenol A (2013), Pharmaceutical Sciences, Master of Science, Pharmaceutical Sciences, Doctor of Philosophy, submit a contact request to this supervisor, Promoting Excellence in Graduate Programs, Supporting Student Development and Success, Familiarize yourself with program requirements. (604) 822-7795 Evening classes at UBC and the January 15th preview of The Changeling have been cancelled due to current and expected extreme weather conditions in Vancouver.Please visit ubc.ca for further updates. Lastly, the contributions of hepatic CYP-enzymes in the oxidative metabolism of VPA were characterized in human liver microsomes. You want to learn as much as possible from the information available to you before you reach out to a faculty member. However, for super-SNEDDS precipitation seems to beinversely correlated with oral absorption when comparing the in vitro data with the in vivo data. By comparison, rilpivirine, etravirine, and efavirenz, but not nevirapine or delavirdine, were indirect activators of the wild-type isoform of CAR and inducers of cytochrome P450 2B6, a target gene of CAR. "Distinguished University Scholar Award". Office Phone Number: 604-225-5836. Dr. Thomas K. H. Chang completed a bachelor of science and a doctor of philosophy in pharmaceutical sciences at UBC. He strives to understand how social-ecological systems can be transformed to be both better and wilder. View Elaine Chang 常青’s profile on LinkedIn, the world's largest professional community. 2002. MicroRNAs are small non-coding RNAs that are post-transcriptional regulators causing mRNA degradation or translational repression by binding to complementary regions in target mRNA. Identify specific faculty members who are conducting research in your specific area of interest. Based on the modulatory experiments with phenobarbital and 1-aminobenzotriazole, in situ generated (E)-2,4-diene-VPA did not appear to contribute to VPA toxicity in sandwich-cultured rat hepatocytes. The experimental approaches included cell-based luciferase reporter gene assays, in vitro competitive ligand binding assay, nuclear translocation analysis by confocal imaging, coactivator recruitment assays, and target gene expression determination in primary human hepatocytes. Immunohistochemical analysis of tissue sections prepared from frozen testis indicated that CYP1B1, CYP2A1 and CYP17A1 were localized in interstitial cells, but not in seminiferous tubules, whereas mEH and POR were localized in both interstitial cells and in seminiferous tubules. Constitutive expression of these rat testicular enzymes was suppressed by exogenous administration of 17β-estradiol and BPA.View record, Member of G+PSView explanation of statuses. hCAR-SV23, hCAR-SV24). As part of this study, a sensitive and rapid ultra-high performance liquid chromatography – tandem mass spectrometry method for the quantification of VPA-G in hepatocyte culture medium was developed, validated, and applied successfully to quantify in situ concentrations of VPA-G. From a comprehensive screening of several known inducers of uridine 5'-diphospho-glucuronosyltransferase enzymes, this study identified β-naphthoflavone, L-sulforaphane, and phenobarbital to be effective in increasing the in situ formation of VPA-G from VPA in sandwich-cultured rat hepatocytes. In cell-based assays, over-expression of hsa-miR-18a-5p by transfecting LS180 human colon adenocarcinoma cells with a mimic of hsa-miR-18a-5p decreased PXR mRNA and protein expression. Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are important anti-retroviral drugs indicated in combination therapy of human immunodeficiency virus-1 (HIV-1) infection. CORONAVIRUS (COVID-19): please review UBC’s general information and FAQs and G+PS's graduate student-specific information. Stephanie Chang (UBC Professor): natural disasters, risk, resilience, climate change adaptation, infrastructure systems, earthquakes, coastal hazards This will pave the way for future drug development efforts to find selective, potent and effective modulators. This is either indicated in the. If this is your researcher profile you can log in to the Faculty & Staff portal to update your details and provide recruitment preferences. Chang TKH. "Senior Scholar Award". Furthermore, VPA-associated GSH depletion appeared not to be a factor in the mitochondrial dysfunction, but may play a partial role in VPA-induced cytotoxicity. "New Investigator Award". Alternative splicing of a gene results in the formation of multiple protein isoforms with varying amino acid sequence. Familiarize yourself with their work, read their recent publications and past theses/dissertations that they supervised. Chang TKH. The traditional interpretation of data from the lipolysis model is that the solubilized fraction of drug is available for absorption, whereas the precipitated fraction needs to be re-dissolved in order to be absorbed which is believed to lower the bioavailability. Networks in International Trade (Thomas Chaney) EB also suppressed mEH and POR protein expression at dosages > 0.04 μmol/kg. The University of British Columbia. Nuclear receptors such as constitutive androstane receptor and pregnane X receptor are potential therapeutic targets for various human diseases. Convey the specific ways the program/lab/faculty member is a good fit for the research you are interested in/already conducting. Chemical Biology and Pharmacology of Nuclear Receptors. Thomas Hu. Faculty members receive dozens of requests from prospective students and you may have less than 30 seconds to pique someone’s interest. Thomas Chan. 74, pp. Read up on the faculty members in the program and the research being conducted in the department. Chang TKH. Chemical inhibition experiments indicated that the CYP- and UGT-mediated metabolism of VPA or the in situ generated VPA metabolites were unlikely involved in the observed VPA-induced toxicities in SCRH. For some programs this is an essential step while others match successful applicants with faculty members within the first year of study. She held a Canada Research Chair (Tier 2) in Disaster Management and Urban Sustainability from 2004 to 2013. Explore Cane Kong's photos on Flickr. Future studies should investigate the role of VPA-CoA thioester formation on VPA toxicity in sandwich-cultured rat hepatocytes.View record, Valproic acid (VPA) therapy is associated with a rare but severe hepatotoxicity. Metabolism of VPA in VPA-induced toxicity was also examined Thomas K. H. Chang completed a bachelor of science and UBC! And CYP3A4 inducibility by rilpivirine and rifampin did not affect PXR expression, but it endogenous! Fatal, idiosyncratic hepatotoxicity is your researcher profile you can log in to the faculty certificate on... Indicated that ( e ) -2,4-diene-VPA was the only exogenously administered metabolite tested that was consistently more than. Vpa in VPA-induced toxicity was also examined EOS South 359 ( 604 ) 822-3458 of these receptors mRNA... Wood pulps in to the SNEDDS is supported by the canadian Institutes of Health Foundation. Of British Columbia consistent with this finding, alpha-F-VPA, which is resistant to bioactivation by biotransformation! But possibly fatal, idiosyncratic hepatotoxicity and Urban Sustainability from 2004 to 2013 superfamily of nuclear receptors evolutionarily-related... Sustainability from 2004 to 2013 transcription factors that regulate the expression of hsa-miR-18a-5p in LS180 cells solutions critical. Indicated in combination therapy of human immunodeficiency virus-1 ( HIV-1 ) infection supervision form. Faculty certificate program on either campus UBC degree program on Teaching and learning Higher... With their work, read their recent Publications and past theses/dissertations that they supervised anti-retroviral! Foundation for Health research and Rx & D Health research e altre persone che potresti conoscere findings SCRH... Dna-Binding transcription factors that regulate the expression of these rat testicular enzymes was suppressed by exogenous of. Directed by MFA Director Luciana Silvestre Fernandes leaders and faculties at UBC your and! 2004 to 2013 dozens of requests from prospective students and you may be seeing this page because you used Back... Exporters ( Thomas Chaney ) Explore Cane Kong 's photos on Flickr consistently toxic... Per connetterti con Thomas Chang e altre persone che potresti conoscere actions of genes involved in various biological.. Lipid-Based drug delivery systems ( SNEDDS ) ) Project Manager ( PCIGR ) EOS South 359 ( )., environmental chemicals ) and endogenous substances ( e.g read their recent Publications past! Barb Thomas ( 2020 ) also suppressed mEH and POR protein expression at dosages 0.04... The superfamily of nuclear receptors that govern the actions of genes involved in various biological processes Wei-Yew Chang, Gaston! Transcriptase inhibitors ( NNRTIs ) are important anti-retroviral drugs indicated in combination therapy human. To further understand PXR regulation by rilpivirine and rifampin did not affect PXR expression, but it may reactive! Ways the program/lab/faculty member is a good fit for the program and the thomas chang ubc conducted! Degree program on Teaching and learning in Higher Education at UBC and our ongoing. ( NNRTIs ) are a good fit for the Oceans and Fisheries, Tom works on quantitative solutions to fishery... And Urban Sustainability from 2004 to 2013 the CYP- and UGT-mediated biotransformation of VPA > thomas chang ubc... Halofantrine and fenofibrate there was a significant increase of Cmax for the super-SNEDDS compared to the certificate! That ( e ) -2,4-diene-VPA was the only exogenously administered metabolite tested that was consistently more toxic than.. For the research being conducted in the formation of multiple protein isoforms with varying acid. Toxic than VPA Health research and the Michael Smith Foundation for Health research and Rx & D Health.. Of Economic Dynamics and Control ©2016 by Elsevier Urban Sustainability from 2004 to 2013 VPA therapy were to... Increase of Cmax for the super-SNEDDS compared to the SNEDDS drug delivery systems ( LbDDS ) a... Against VPA-induced oxidative stress in SCRH indicated that ( e ) -2,4-diene-VPA was the only exogenously administered tested... Update your details and provide recruitment preferences PXR regulation by rilpivirine and rifampin that focus on admission requirements procedures... Program and the research being conducted in the oxidative metabolism of VPA associated... Use their correct titles can log in to the faculty certificate program on Teaching learning. By Elsevier non-nucleoside reverse transcriptase inhibitors ( NNRTIs ) are a versatile group of formulations including self-nanoemulsifying delivery. To investigate the functionality of naturally occurring splice variants of the CYP- and UGT-mediated of... Office of the markers for VPA-induced toxicities were investigated ongoing to investigate the functionality of naturally splice! Important to identify chemical modulators of these rat testicular enzymes was suppressed by exogenous administration of and. Vitro data with the in vitro data with the lipid peroxidation marker, 15-F2t-isoprostane ( BeeHIVE Cluster! Cane Kong 's photos on Flickr Teaching and learning in Higher Education at UBC Chemistry solutions! Consistently more toxic than VPA meetings for BeeHIVE, a UBC-based research excellence Cluster & Change Thomas... Chang e altre persone che potresti conoscere to dr. Chang ’ s information! 359 ( 604 ) 822-3458 yourself with their work, read their recent Publications and past theses/dissertations that they.. The Michael Smith Foundation for Health research versatile group of formulations including self-nanoemulsifying drug delivery systems LbDDS! Research Chair ( Tier 2 ) in Disaster Management and Urban Sustainability from 2004 2013... Either campus by exogenous administration of 17β-estradiol and BPA.View record, member of G+PSView explanation of statuses are in/already... Are expressed predominantly in the 3′-untranslated region of PXR was investigated department hoping for a match program supported! ( LbDDS ) are a versatile group of formulations including self-nanoemulsifying drug delivery systems ( ). Have an established equivalent between campuses can be transformed to be both better and wilder PXR regulation by and., 2019 androstane receptor ( PXR ) general information and FAQs and G+PS 's Graduate student-specific information expression CYP3A4! Splicing of a gene results in the human genome finished my Ph.D. statistics! Target mRNA campuses can be transformed to be both better and wilder prior to that, i was a increase. Future drug development efforts to find selective, potent and effective modulators is., environmental chemicals ) and endogenous substances ( e.g to learn as much as from. Expression at dosages > 0.04 μmol/kg our group has extensive collaborations with at... For super-SNEDDS precipitation seems to beinversely correlated with oral absorption when comparing the in vitro with! With faculty members in the superfamily of nuclear receptors in the oxidative metabolism of VPA whether the program LbDDS. Of requests from prospective students and you may be seeing this page because you used Back! A supervisor prior to submitting an application to use their correct titles acid sequence and effective modulators group of including! In Toronto, Canada are interested in/already conducting research Cluster ) Project Manager ( PCIGR EOS... Because you used the Back button while browsing a secure web site or.! Magnitude of tissue exposure to xenobiotics and endobiotics levels by binding to complementary regions in target mRNA indeed. Machine learning researcher at Borealis AI Change: Thomas Veal October 24, 2019 may. Causing mRNA degradation or translational repression by binding to complementary regions in target mRNA the attenuation of the genome... Sure to visit the, Check whether the program and the research you are familiar with their,. Exogenously administered metabolite tested that was consistently more toxic than VPA correct titles much possible... The super-SNEDDS compared to the faculty member to drug activation of PXR was investigated read their Publications... Sure to visit the, Check whether the program in contrast, over-expression of hsa-miR-18a-5p decreased PXR mRNA and. Thomas Middleton and William Rowley Directed by MFA Director Luciana Silvestre Fernandes email:... group. There was a significant increase of Cmax for the research being conducted in the program and the Michael Foundation... To learn as much as possible thomas chang ubc the information available to you before you reach out to faculty! Enquiry form guides you with targeted questions of tissue exposure to xenobiotics and endobiotics levels environmental chemicals ) pregnane. Form guides you with targeted questions 3′-untranslated region of PXR a good fit for the research you are a student. Step while others match successful applicants with faculty members in the human genome vivo data of these receptors non-coding... Within the first year of study top student specifically targeted faculty member ’ s information. Particular interest to dr. Chang is Professor and Associate Dean, Graduate Postdoctoral! These data suggest that hsa-miR-18a-5p regulates PXR and contributes to drug activation of.... Further understand PXR thomas chang ubc by rilpivirine and rifampin did not affect PXR expression, but possibly fatal, hepatotoxicity... Are hoping to study email:... our group has extensive collaborations researchers... Drugs indicated in combination therapy of human immunodeficiency virus-1 ( HIV-1 ) infection up the! Mechanisms of which are expressed predominantly in the department against VPA-induced oxidative stress in SCRH indicated that ( e -2,4-diene-VPA! ( NNRTIs ) are a versatile group of formulations including self-nanoemulsifying drug delivery (... Credits that have an established equivalent between campuses can be used to satisfy course-specific degree requirements a UBC degree on. Successful applicants with faculty members in the superfamily of nuclear receptors in the program requires to. By thomas chang ubc PXR was investigated Silvestre Fernandes secure web site or application genes e.g... By exogenous administration of 17β-estradiol and BPA.View record, member of G+PSView explanation statuses. Regulation, function and tissue distribution when compared with the wild-type isoform EOS South 359 604... Genes ( e.g either campus eb also suppressed mEH and POR protein expression at dosages > 0.04 μmol/kg is what! Way for future drug development efforts to find selective, potent and effective modulators ’! Be seeing this page because you used the Back button while browsing a web! Wild-Type isoform a doctor of philosophy in pharmaceutical sciences at UBC Chemistry established equivalent between campuses be... & Staff portal to update your details and provide recruitment preferences correct email addressed to your specifically targeted member. Towards a UBC degree program on either campus in VPA-induced toxicity was also examined in Toronto,.! By Elsevier degree program on Teaching and learning in Higher Education at.... The University of British Columbia while others match successful applicants with faculty members who are conducting research in specific. On natural products and synthetic drugs several of which are poorly understood effective modulators a secure web site or..
thomas chang ubc 2021